New therapy helps immune cells detect, kill cancer in early tests

    Source: Xinhua| 2018-07-03 01:41:52|Editor: mmm
    Video PlayerClose

    WASHINGTON, July 2 (Xinhua) -- American researchers reported in a preclinical models that they can amplify macrophage immune responses against cancer using a self-assembling supramolecule.

    A study published on Monday in the journal Nature Biomedical Engineering showed that macrophages, immune cells that engulf and digest particles and pathogens, provided a first line of defense against bacteria and viruses and can also help destroy cancer cells.

    Macrophages play a paradoxical role, with M1s anti-tumorigenic, but inflammation-quelling M2s recruited by tumor cells to help them grow, according to the researchers.

    Also, tumors can send out "eat me not" signal that tricks M1 macrophages into letting them be, and in this way, pro-tumorigenic macrophages may make up 30 to 50 percent of a tumor's mass.

    Investigators have developed a therapeutic that delivers double attack to knock out these mechanisms.

    They re-programed the M2s into M1s by inhibiting the M2 signaling pathway, re-educating the macrophages and inhibiting the "don't eat me" protein.

    To address both the M2 "re-education" problem and to enhance the macrophages' capacity to eat tumor cells, the researchers used what they call a bi-functional or "one-two punch."

    They used a multi-component supramolecular system that self-organizes at the nanoscale to deliver an antibody inhibitor plus a drug inside the tumor.

    "This is the first time anyone has combined these two, a drug that targets M2 macrophages and an antibody that inhibits 'don't eat me signal,' in one delivery system," said Ashish Kulkarni at Department of Chemical Engineering of the University of Massachusetts Amherst.

    "We tested it in melanoma and breast cancer preclinical models, two aggressive cancers, and we plan to try it on different types of cancer and in combination with other current therapies like T-cell-based therapies now used in clinics," said Kulkarni.

    Mice that were untreated formed large tumors by Day 10, mice treated with currently available therapies showed decreased tumor growth, but mice treated with the new supramolecular therapy had complete inhibition of tumor growth, the reported.

    The team also reported an increase in survival and a significant reduction in metastatic nodes.

    The paper's co-author Shiladitya Sengupta at Brigham and Women's Hospital said, "We can actually see macrophages eating cancer cells," citing confocal microscopy images in the paper that show macrophages engulfing cancer cells.

    Kulkarni said next steps are to continue testing the new therapy in preclinical models to evaluate safety, efficacy and dosage.

    The supramolecular therapy they have designed has been licensed and they hope to move the therapeutic into clinical trials if preclinical testing continue to show promise.

    TOP STORIES
    EDITOR’S CHOICE
    MOST VIEWED
    EXPLORE XINHUANET
    010020070750000000000000011100001372968171
    主站蜘蛛池模板: 污视频免费网站| 好男人在线观看高清视频www| 亚洲第一福利视频| 国内xxxx乱子另类| 欧美日韩一区二区三区自拍 | 一级毛片在线完整观看| 亚洲国产视频网| 亚洲五月综合缴情婷婷| 亚洲成a人片在线观看中文动漫| 亚洲欧美日韩综合一区| 亚洲国产综合精品中文第一区| 亚洲成AV人片在WWW色猫咪| 亚洲av无码一区二区三区dv| 久久国产精品无码一区二区三区| 久久久久无码精品国产H动漫| 中国国产高清一级毛片| 动漫精品动漫一区三区3d| 免费观看的黄色网址| 亚洲国产av无码专区亚洲av| 国产真实系列在线| 国产国产人免费人成免费视频 | 小蝌蚪视频网站| 色综久久天天综合绕视看| 亚洲国产日韩在线成人蜜芽| 人人妻人人添人人爽日韩欧美| 在车子颠簸中进了老师的身体| 成人综合久久综合| 国外成人免费高清激情视频| 国产强被迫伦姧在线观看无码| 动漫美女被羞羞动漫小舞| 人人妻人人澡人人爽超污| 久草网在线视频| 久久国产精品久久久久久| jazzjazz国产精品一区二区| 992tv国产人成在线观看| 高清欧美性猛交xxxx黑人猛交 | 韩国电影禁止的爱善良的小子hd| 麻豆国产AV丝袜白领传媒| 男女午夜爽爽大片免费| 日韩免费a级毛片无码a∨| 大JI巴好深好爽又大又粗视频|