Study finds new clues in understanding relapse in breast cancer

    Source: Xinhua| 2018-09-06 06:52:33|Editor: Yamei
    Video PlayerClose

    CHICAGO, Sept. 5 (Xinhua) -- A genomic analysis has linked certain DNA mutations to a high risk of relapse in estrogen receptor positive breast cancer, while other mutations were associated with better outcomes, according to U.S. researchers.

    The researchers at Washington University School of Medicine in St. Louis, the Baylor College of Medicine and the University of British Columbia analyzed tumor samples from more than 2,500 patients with estrogen receptor positive breast cancer, one of the most common forms of the disease.

    They found that although mutations in DDR1 and NF1 are rare, they are associated with early relapse, which makes them much more common in patients who unfortunately die from the disease.

    One unique element of the study was the age of the samples. Many were over 20 years old, allowing the researchers to know the full history of how the patients fared.

    The study also confirmed past work showing that relatively common mutations in genes called MAP3K1 and TP53 had opposite effects on tumor aggressiveness. Patients with MAP3K1 mutations did well, while those with TP53 mutations were likely to have a recurrence.

    The study has identified three genes, namely DDR1, PIK3R1 and NF1, with relatively uncommon mutations that were associated with cancer recurrence and spreading.

    "We would like to help doctors identify patients who are likely to do well versus those who are likely to have a recurrence," said first author Obi L. Griffith, an assistant professor of medicine and an assistant director of the McDonnell Genome Institute at Washington University School of Medicine.

    "Those with mutations that are associated with a good prognosis may need less intensive therapy than they might otherwise receive. But if a patient's tumor has mutations linked to high risk of relapse, it's useful to know that early so they can be treated with more aggressive therapies or even potential investigational therapies that could be targeted to their specific mutations," Griffith added.

    The researchers also pointed out the importance of continuing to sequence cancer genomes.

    More than 266,000 women in the United States are diagnosed with invasive breast cancer each year, according to the American Cancer Society, and about 70 percent of cases are estrogen receptor positive.

    The study was published on Tuesday in the journal Nature Communications.

    TOP STORIES
    EDITOR’S CHOICE
    MOST VIEWED
    EXPLORE XINHUANET
    010020070750000000000000011103261374478871
    主站蜘蛛池模板: 最近2019在线观看| poverty中国老妇人| 波多野结衣被躁| 国产绳艺sm调教室论坛| 久久久久夜夜夜精品国产| 欧美老熟妇又粗又大| 四影虎影ww4hu32海外| 日本三级韩国三级美三级91| 好男人资源在线www免费| 久久国产免费观看精品| 欧美性xxxx禁忌| 免费永久国产在线视频| 调教羞耻超短裙任务| 国产精品久久国产精品99| a级毛片免费全部播放| 扒开双腿猛进入女人的视频| 亚洲AV无码精品色午夜果冻不卡| 激情综合一区二区三区| 国产91乱剧情全集| 成人免费观看一区二区| 国内精品福利视频| 一区二区三区欧美视频| 日本3p视频在线看高清| 免费观看a黄一级视频| 风间中文字幕亚洲一区中文馆| 国产精品福利电影| 久久乐国产精品亚洲综合| 第四色最新网站| 国产精品久久久久鬼色| a级毛片免费观看网站| 成人美女黄网站视频大全| 亚洲欧洲另类春色校园网站| 精品久久久无码人妻中文字幕豆芽 | 国产精品福利一区二区久久| 一个人看的www视频免费在线观看| 日本丶国产丶欧美色综合| 伊人蕉久中文字幕无码专区 | 91在线手机精品免费观看| 女人色毛片女人色毛片中国| 中文字幕亚洲欧美| 日本丰满岳乱妇中文|